R&D contracts in Missouri
Federal research and development work in Missouri that is set aside for small businesses. As of Oct 17, 2026: 0 open notices, 2 set-aside contracts ending in the next 6 to 18 months, and 12 new set-aside awards in the last 12 months.
Covers NAICS 5417 (Scientific Research and Development Services). Place of performance: Missouri.
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Your alert: NAICS 5417 · Missouri. Free, every weekday.
No open notices for this trade in Missouri today. New ones are posted daily, so set an alert above or see all open bids in Missouri.
Contracts ending soon (recompetes)
| Score | Incumbent | Agency | Industry | State | Total obligated | Ends |
|---|
| 90 | SEMPRE, INC. CUAS STRIKER PACKAGE AND BASE AREA LAYER NETWORK (SEMPRE T) SUPPORT. THE RESPONSE TO… Why 90? ends in 11 mo · no option years left · $45M · 1 offer last time · standalone contract- Ends in about 11 months (Sep 30, 2027). +20/30
- No unexercised option years on record, so new work likely has to be awarded when it ends. +20/20
- $45M obligated so far. +20/20
- Last time it was competed under simplified acquisition procedures, and only 1 offer came in. +20/20
- Standalone contract, so the follow-on is not tied to an existing vehicle. +10/10
| Department of Defense Department of the Air Force | Research and Development in the… | MO | $44,761,105 | Sep 30, 2027 |
| 86 | ZENO POWER SYSTEMS INC. (RPS) RADIOISOTOPE POWER SYSTEM Why 86? ends in 10 mo · no option years left · $15M · 2 offers last time · standalone contract- Ends in about 10 months (Aug 20, 2027). +23/30
- No unexercised option years on record, so new work likely has to be awarded when it ends. +20/20
- $15M obligated so far. +16/20
- Last time it was competed among eligible firms (set-aside competition) with 2 offers. +17/20
- Standalone contract, so the follow-on is not tied to an existing vehicle. +10/10
- The incumbent has held it since 2022 (about 4 years).
| Department of Defense Department of the Air Force | Research and Development in the… | MO | $14,997,863 | Aug 20, 2027 |
Who wins this work in Missouri
| Company | Set-aside $ obligated |
|---|
| Sempre, Inc. | $44,761,105 |
| Thermavant Technologies LLC | $1,696,042 |
| Product Innovation and Engineering LLC | $1,289,491 |
| Boeing Aerospace Operations, Inc. | $182,734 |
| New South Associates, Inc. | $160,935 |
Top buyers: Department of Defense ($47,135,050), National Aeronautics and Space Administration ($1,274,494), Department of the Interior ($113,458).
Source: USAspending.gov, small-business set-aside contracts for NAICS 5417 performed in Missouri, Oct 18, 2025 to Oct 18, 2026. Dollars are net obligations in the period. Refreshed weekly.
Free local help: APEX Accelerators in Missouri
APEX Accelerators give small businesses no-cost, one-on-one help with SAM.gov registration, finding bids and preparing proposals. The program is funded by the Department of War (formerly Defense) Office of Industrial Base Growth.
- Missouri APEX Accelerator Main Office · Columbia (573) 882-8058
- Missouri APEX Accelerator (University of Missouri System) · Columbia (816) 235-6083
- MO APEX Accelerator Columbia 1 · Columbia (573) 882-9398
Serves: Adair, Audrain, Benton, Boone, Callaway, Camden, Chariton, Clark, Cole, Cooper, Howard, Knox, Lewis, Linn, Macon, Maries, Marion, Miller,…
- MO APEX Accelerator Kansas City · Kansas City 816 235-2891; (816) 235-6083
Serves: Andrew, Atchison, Bates, Buchanan, Caldwell, Cass, Caroll, Clay, Clinton, Daviess, DeKalb, Gentry, Grundy, Harrison, Henry, Holt, Jackson,…
- MO APEX Accelerator Springfield · Springfield (417) 837-2612
Serves: Barry, Barton, Cedar, Christian, Dade, Dallas, Greene, Hickory, Jasper, Laclede, Lawrence, McDonald, Newton, Polk, Pulaski, St. Clair,…
- MO APEX Accelerator St. Louis County · St. Louis 314-403-7410; 314-400-7378; 314-376-5375
Serves: Crawford, Franklin, Gasconade, Iron, Jefferson, Lincoln, Madison, Montgomery, Pery, Pike, St. Charles, St. Francois, St. Louis, Ste.…
- MO APEX Accelerator West Plains · West Plains (417) 256-2391
Serves: Bollinger, Butler, Cape Girardeau, Carter, Dent, Douglas, Dunklin, Howell, Mississippi, New Madrid, Oregon, Ozark, Pemiscot, Reynolds,…
Source: official APEX Accelerators directory, checked Oct 18, 2026. AwardWatchdog is independent and not affiliated with the APEX Accelerators program.
Frequently asked questions
How many federal research and development set-aside contracts are open in Missouri?
As of Oct 17, 2026, AwardWatchdog lists 0 open small-business set-aside or early-stage notices for research and development work performed in Missouri (NAICS 5417), from SAM.gov.
Who wins research and development set-aside contracts in Missouri?
From Oct 18, 2025 to Oct 18, 2026, USAspending.gov shows 12 new small-business set-aside contract awards for this work performed in Missouri. The largest recipient by dollars obligated was Sempre, Inc. ($44,761,105), and the biggest buyer was Department of Defense.
Where can I get free help bidding on federal contracts in Missouri?
Missouri is served by Missouri APEX Accelerator Main Office, Missouri APEX Accelerator (University of Missouri System), MO APEX Accelerator Columbia 1 and others. APEX Accelerators give small businesses free help with registration, bid searches and proposals (official directory checked Oct 18, 2026).
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